Testosterone Thyroid and Stem Cells

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Testosterone Thyroid and Stem Cells

 

Hormones affect nearly every cellular process in the body and rightly have an impact on clinical outcomes in stem cell therapies. To clinically optimize the potential benefit of regenerative injection and stem cell therapies, it is important to evaluate your hormonal status overall.

Testosterone’s beneficial androgenic effects on wound healing, immune status and inflammatory responses during acute wound healing have all been well documented. Regarding regenerative medicine, injection of testosterone and optimization of thyroid may lead to improved outcomes in stem cell therapies.

Testosterone is anabolic and as such promotes tissue deposition and growth. This is well accepted and has been shown in the literature. The very premise of its anabolic effects logically lends itself to being helpful in orthopedic regenerative practices which of course include treatments for arthritis, chronic pain, and knee pain and back pain.

Testosterone is being used as an injectate to stimulate tissues locally in prolotherapy treatments for ligamentous laxity with good results. Testosterone has been shown to increase circulating endothelial progenitor cell numbers in men with late onset hypogonadism as well as promotes angiogenesis by increasing stromal cell-derived factor 1a (SDF-1a) and vascular endothelial growth factor. This is but one mechanism that impacts stem cell therapy outcomes.

 

Thyroid hormone is a metabolic hormone that is a known stimulator of growth and metabolic rate. When thyroid is subclinically or clinically low it leads to decreased wound healing in patients. Even topical use of the hormone has been shown to increase healing.

Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid replacement to regenerate and reduce pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3 has accelerated wound healing and hair growth in rodents. Topical T4 has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat pathology may be of large consequence and merits further study.

It is logical to assume that without optimal thyroid hormone status that stem cell therapies will not be as effective. In mammals it has been shown that stem cell proliferation is decreased, as is mitosis, due to hypothyroidism.

There are other known critical hormones that impact stem cell development, viability and differentiation in the body. The hormonal milieu of a patient is critical and should be clinically addressed prior to administration of stem cell therapies for optimal outcomes in treatment.

 

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