Low levels of testosterone are associated with a wide range of disease processes in men. An overwhelming volume of data shows that higher levels of testosterone protect against disorders as diverse as Alzheimer’s dementia. type II diabetes, abdominal obesity, osteoporosis, muscle wasting, depression, cognitive decline, loss of libido, inflammatory-related syndromes, and a range of cardiovascular diseases.
There is evidence to suggest that low concentrations of testosterone are associated with an increased risk of cardiovascular disease in men. Also Serum F-testosterone concentration is inversely associated with carotid atherosclerosis.
Higher testosterone levels are associated with better cognitive performance in the oldest age category.
In one study a 52-week treatment with diet and exercise plus transdermal testosterone reversed the metabolic syndrome and improved glycaemic control in men with newly diagnosed type II diabetes and subnormal plasma testosterone. HgBA1c, fasting plasma glucose, HDL-cholesterol, triglyceride concentrations, and the waist circumference improved with this treatment.
Testosterone treatment reduced elevated levels of inflammatory cytokines in a group of men with CHD in another study. This dialing-down of the systemic inflammatory state may have salutary stabilizing effects on atherosclerotic plaques. Further work is required to determine whether and why physiologic testosterone levels in the high normal range appear to be conducive to optimal cardiovascular health for adult men.
A study has shown that low free and bioavailable testosterone concentrations in the normal range were associated with diabetes. These data suggest that low androgen levels may be a risk factor for diabetes in men.
English et al. showed in their study that low dose supplemental testosterone treatment in men with chronic stable angina reduces exercise-induced myocardial ischemia.
To be continued…